The Cholesterol Conspiracy Podcast by Ladd McNamara, M.D.

In this episode Dr. Ladd McNamara discusses vitamins, minerals, antioxidants, and essential fatty acids: a real an alternative way to reduce the risk of death from heart disease and stroke.

• Chapter 33: Vitamins, Minerals, Antioxidants, and Essential Fatty Acids: The Real Way to Reduce the Risk of Death from Heart Disease and Stroke – Part 2

Chapter Excerpts

Studies using levels of vitamin C, well above 700 mg per day have shown a decreased risk of diseases, including the risk of heart disease.

Ladd McNamara, M.D.

Bioflavanoids such as grape seed extract, resveratrol, & quercetin all have shown remarkable results in reducing the risk of heart disease and cancers. They work synergistically, as well as with other antioxidants to reduce the risk of disease.

L-carnosine may slow down the aging process, and protects the brain, skin, and arteries from damage. Furthermore, L-carnosine helps the heart to contract more effectively through enhancing the use of calcium.

Chapter References

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• 96: Hoffman RM, et al. Antioxidants and the prevention of coronary heart disease. Arch Int Med. 1995 155:241-244.
• 97: Morrison H, et al. Serum folate and risk of fatal coronary heart disease. J Am Med Assoc. 1996 275:24:1893-1896.
• 98: Chasan-Taber L, et al. A prospective study of folate and vitamin B-6 and risk of myocardial infarction in U.S. physicians. J Am Coll Nutri. 1996 15:2:136-143.
• 99: Levine GN, et al. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation. 1996 93:6:1107-1113.
• 100: Gatto LM, et al. Ascorbic acid induces a favorable lipoprotein profile in women. J Am Coll Nutri. 1996 15:2:154-158.
• 101: Hallfrisch J, et al. High plasma vitamin c associated with high plasma HDL (1) – and HDL (2) cholesterol. Am J Clin Nutri. 1994 60:100-105.
• 102: Osganian S, Stampfer M, Rimm E, Spiegelman D, et al. Vitamin C and risk of coronary heart disease in women. J Am Coll Cardiol. 2003 42:246-252.
• 103: Rifici V, Khachadurian A. Dietary supplementation with vitamins C and E inhibits in-vitro oxidation of lipoproteins. J Am Coll Nutri. 1993 12:6:6331-6337.
• 104: Gaziano J. Antioxidant vitamins and coronary artery disease risk. Am J Med. 1994 97:3A-18S-3A-21S.
• 105: Lagrue G, et al. A study of the effects of procyanidol oligomers on capillary resistance in hypertension and in certain nephropathies. Sem Hop Paris. 1981 57:1399-1401.
• 106: Detre A, et al. Studies on vascular permeability in hypertension: action of anthocyanosides. Clin Physiol Biochem. 1986 4:143-149.
• 107: Meunier MT, et al. Free-radical scavenger activity of procyanidolic oligomers and anthocyanosides with respect to superoxide anion and lipid peroxidation. Plant Medphytother. 1989 4:267-274.
• 108: Tixier J, et al. Evidence by in vivo and in vitro studies that binding of pycnogenols to elastin affects its rate of degradation by elastases. Biochem Parmacol. 1984 33:3933-3939.
• 109: Facino R, et al. Free-radical scavenging action and anti-enzyme activities of procyanidines from vitis vinifera; a mechanism for their capillary protective action. Arzneimittel-Forschung Drug Research. 1994 44(1):5:592-601.
• 110: Dartenuc JY, et al. Capillary resistance in the geriatric: study of a micro-angioprotector. Bordeaux Medicale. 1985 13:903.
• 111: Kuhnau J. The flavonoids, a class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet. 1976 24:117-191.
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• 113: Knekt P, et al. Flavonoid intake and coronary mortality in finland: a cohort study. Brit Med J. 1996 312:478-481.
• 114: Stephens N, et al. Randomized Controlled Trial of Vitamin E in Patients with Coronary Disease: Cambridge Heart Anti-Oxidant Study (CHAOS). The Lancet. 1996 347:781-786.
• 115: Niki E, et al. Interaction among vitamin C, vitamin E, and beta carotene. Am J Clin Nutri. 1995 62(suppl):1322S-1326S.
• 116: Morrison H, et al. Serum folate and risk of fatal coronary heart disease. J Am Med Assoc. 1996 275:24:1893-1896.
• 117: Carr A, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr. 1999 69(6):1086-1107.
• 118: Enstrom J. Counterpoint–vitamin C and mortality. Nutr Today. 1993 28:28-32.
• 119: Osganian S, Stampfer M, Rimm E, et al. Vitamin C and risk of coronary heart disease in women. J Am Coll Cardiol. 2003 42(2):246-252.
• 120: Keli S, et al. Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Intern Med 1996 Mar 25;156?6):637-642.
• 121: Duarte J, et al. Antihypertensive effects of the flavonoids quercetin in spontaneously hypertensive rats. Br J Pharmacol 2001 133:117-24.
• 122: Maron D, Lu G, Cai N, et al. Cholesterol-lowering effect of a theaflavin-enriched green tea extract. A randomized controlled trial. Arch Intern Med. 2003;163:1448-1453.
• 123: Preston JE, Hipkiss AR, Himsworth DT, et al. Toxic effects of betaamyloid (25-35) on immortalized rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alamine. Neurosci Lett. 1998 242(2):1-0-108.
• 124: Stadman ER. Protein oxidation and aging. Science. 1992 257(5074):1220-1224.
• 125: Munch G, Schinzel R, Loske C, et al. Alzheimer’s disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. Journal of Neural Transmission. 1998 105(4-5):439-461.
• 126: Bierhaus A, Hofmann MA, Ziegler R, et al. AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE Concept. Cardiovascular Research. 1998 37(3)586-600.
• 127: McFarland GA, Holliday R. Retardation of the senescence of cultured human diploid fibroblasts by carnosine. Exp Cell Res. 1994 212(2):167-175.
• 128: Zaloga GP, Roberts PR, Black KW. Carnosine is a novel peptide modulator of intracellular calcium and contractility in cardiac cells. Am J Physiol 1997 272(1 Pt 2):H462-468.
• 129: Roberts PR, Zaloga GP. Cardiovascular effects of carnosine. Biochemistry (Mosc) 2000 Jul;65(7):856-861.

Ladd McNamara, M.D.

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