In this episode Dr. McNamara discusses The Real Importance of LDL Cholesterol and The Role of Diabetes and High Blood Sugar in the Development of Coronary Artery Disease
- Chapter 31: The Importance of LDL Cholesterol
- Chapter 32: The Role of Diabetes and High Blood Sugar in the Development of Coronary Artery Disease
Chapter Excerpts
Evidence supports the theory that when a person’s total cholesterol drops below 160, the immune system is weakened. Statin drugs, i.e., cholesterol-lowering drugs, are known to suppress the immune system.
Obesity leads to diabetes through oxidation of insulin receptors, and along with the oxidation of lipids (including cholesterol) and inflammation of the arterial wall leads to heart disease, stroke, and eventually death.
Chapter References
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- 76: Somogyi A, et al. Hypothetical connection between diabetes mellitus and free radical reactions in arteriosclerosis. Orvosi Hetilap [Hungarian] 1994 135:(33):1815-1818.
- 77: Jialal I. Effect of combined supplementation with alpha-tocopherol ascorbate and beta-carotene on low-density lipoprotein oxidation. Circulation. 1993 88:2780-2786.
- 78: Munch G, Mayer S, Michaelis J, et al. Influence of advanced glycation end-products and AGE-ingivitors on nucleation-dependent polymerization of beta-amyloid peptide. Biochim Biophys Acta. 1997 1360(1):17-29.
- 79: Hipkiss A, Michaelis J, Syrris P. Non-enzymatic glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking agent. FEBS Lett. 1995 371(1):81-85.
- 80: Brownson C, Hipkiss A. Carnosine reacts with a glycated protein. Free Radic Biol Med. 2000 28(10):1564-1570.
- 81: Yamano T, et al. Effect of L-carnosine on the hyperglycemia caused by intracranial injection of 2-deoxy-D-glucose in rats. Neurosci Lett 2001 Nov 2;313(1-2):78-82.
- 82: Heitzer T, et al. Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress. Free Radic Biol Med 2001 Jul 1;31(1):53-61.
- 83: El Midaoui A, de Champlain J. Prevention of hypertension, insulin resistance, and oxidative stress by alpha-lipoic acid. Hypertension 2002 Feb;39(2):303-307.
- 84: Takaoka M, et al. Effects of alpha-lipoic acid on deoxycorticosterone acetate-salt-induced hypertension in rats. Eur J Pharmacol 2001 Jul;20;424(2):121-129.
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